A neuropeptide with diverse biological activities
货号:ajcx22256
CAS:2483831-63-4
分子式:C22H25D4FO5
分子量：396.5
溶解度:DMF: 25 mg/ml,DMSO: 30 mg/ml,Ethanol: 3 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Dexamethasone-d₄is intended for use as an internal standard for the quantification of dexamethasone by GC- or LC-MS. Dexamethasone is a synthetic glucocorticoid that binds the human glucocorticoid receptor with a higher affinity than a natural ligand, cortisol (K_d= 5 nMversus17 nM, respectively).¹Through receptor activation, dexamethasone has both transactivating and transrepressing effects on gene expression, producing, in general, anti-inflammatory results.²

1.Mulatero, P., Panarelli, M., Schiavone, D., et al.Impaired cortisol binding to glucocorticoid receptors in hypertensive patientsHypertension30(5)1274-1278(1997) 2.Beck, I.M., Vanden Berghe, W., Vermeulen, L., et al.Crosstalk in inflammation: The interplay of glucocorticoid receptor-based mechanisms and kinases and phosphatasesEndocr. Rev.30(7)830-882(2009)