An internal standard for the quantification of 1,3,7-trimethyluric acid
货号:ajcx21022
CAS:117490-42-3
分子式:C8HD9N4O3
分子量：219.2
溶解度:DMF: 10 mg/ml,DMSO: 10 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 1 mg/ml
纯度：98%
存储：Store at -20°C
库存：现货

Background:

1,3,7-Trimethyluric acid-d₉is intended for use as an internal standard for the quantification of 1,3,7-trimethyluric acid by GC- or LC-MS. 1,3,7-Trimethyluric acid is a derivative of uric acid and a metabolite of caffeine .¹It is formed from caffeine by the cytochrome P450 (CYP) isoform CYP3A4. 1,3,7-Trimethyluric acid (500 µM) scavenges hydroxyl radicals in a cell-free assay and inhibitst-butyl hydroperoxide-induced lipid peroxidation by 56.5% in isolated human erythrocyte membranes.²

1.Tassaneeyakul, W., Birkett, D.J., McManus, M.E., et al.Caffeine metabolism by human hepatic cytochromes P450: contributions of 1A2, 2E1 and 3A isoformsBiochem. Pharmacol.47(10)1767-1776(1994) 2.Bhat, V.B., Sridhar, G.R., and Madyastha, K.M.Efficient scavenging of hydroxyl radicals and inhibition of lipid peroxidation by novel analogues of 1,3,7-trimethyluric acidLife Sci.70(4)381-393(2001)