Phensuximide 是一种具有口服活性的琥珀酰亚胺抗癫痫和抗惊厥药。
货号:ajcx19582
CAS:86-34-0
分子式:C11H11NO2
分子量：189.2
溶解度:DMF: 1mg/mL,DMSO: 15mg/mL,DMSO:PBS (pH 7.2) (1:5): 0.16mg/mL,Ethanol: 10mg/mL
纯度：98%
存储：Store at -20°C
库存：现货

Background:

Phensuximide is an anticonvulsant.1 It inhibits seizures induced by maximal electroshock (MES) and pentylenetetrazole in mice (ED50s = 112 and 50 mg/kg, respectively). Phensuximide (1.25 mmol/kg, i.p.) induces proteinuria and hematuria in rats.2 Formulations containing phensuximide have been used in the treatment of petit mal seizures.

参考文献
1. Kornet, M.J., Crider, A.M., and Magarian, E.O. Potential long-acting anticonvulsants. 1. Synthesis and activity of succinimides containing an alkylating group at the 2 position. J. Med. Chem. 20(3), 405-409 (1977).
2. Rankin, G.O., Cressey-Veneziano, K., Wang, R.T., et al. Urinary tract effects of phensuximide in the Sprague-Dawley and Fischer 344 rat. J. Appl. Toxicol. 6(5), 349-356 (1986).