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Biapenem(CLI 86815)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Biapenem(CLI 86815)图片
CAS NO:120410-24-4
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)350.39
FormulaC15H18N4O4S
CAS No.120410-24-4
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: <1 mg/mL
Water: 16 mg/mL (45.7 mM)
Ethanol: <1 mg/mL
SMILESO=C(C(N12)=C(SC(C3)CN4[N+]3=CN=C4)[C@H](C)[C@]2([H])[C@@H](C(O)C)C1=O)[O-]
SynonymsL-627, LJC-10627; L 627; LJC 10627; L627; LJC10627; CLI 86815; CLI86815; CLI-86815;
实验参考方法
In Vitro

In vitro activity: Biapenem has activity comparable to those of Imipenem and Meropenem against all groups of anaerobes with MICs for 90% of the strains tested of 0.06 to 2 mg/mL. Biapenem is more active than ampicillin-sulbactam, ticarcillin-clavulanate, piperacillin, cefoxitin, cefotaxime, and ceftriaxone. Biapenem is also active against all of the B. capillosus, Prevotella, Clostridium, and Eubacterium strains and anaerobic cocci tested. Biapenem shows broad antibacterial activity against both Gram-positive and Gram-negative clinical isolates. Biapenem is found to be approximately as active as imipenem, inhibiting 90% of isolates of most species at concentrations within one dilution of the MIC of imipenem for 90% of the isolates.

In VivoBiapenem results in significantly fewer viable bacteria than in the lungs of control mice. Biapenem prevents the progression of lung inflammation, including alveolar neutrophil infiltration and hemorrhage. Biapenem significantly prolongs survival and reduces the number of viable bacteria in a murine model of VAP caused by P. aeruginosa.
Animal model
Formulation & Dosage
References

Antimicrob Agents Chemother. 1994 Apr;38(4):889-93; Jpn J Antibiot. 2003 Apr;56(2):138-41; J Infect Chemother. 2012 Aug;18(4):472-8.