RP-72540, formerly known as RPR-102681, is a cholecystokinin B receptor antagonist potentially for the treatment of cocaine abuse. RP 72540 showed selectivity factors in express of 200 for CCKB versus CCKA receptors and also had high affinity for gastrin binding sites in the stomach. Administration of RP-72540 resulted in a dose-dependent inhibition of [3H]pCCK-8 binding in mouse brain homogenate. However, the relative penetration of RP-72540 into the forebrain after peripheral administration was below 0.01%. References: Bertrand P, Bohme GA, Durieux C, Guyon C, Capet M, Jeantaud B, Boudeau P, Ducos B, Pendley CE, Martin GE, et al. Pharmacological properties of ureido-acetamides, new potent and selective non-peptide CCKB/gastrin receptor antagonists. Eur J Pharmacol. 1994 Sep 12;262(3):233-45. PubMed PMID: 7813588.

纯度：≥98%

CAS：139088-45-2