EMD57033 is a troponin activator. It acts by binding to the cardiac/slow skeletal troponin C isoform and is a predominant Ca2+ sensitizer. References: Wang L, Kim K, Parikh S, Cadar AG, Bersell KR, He H, Pinto JR, Kryshtal DO, Knollmann BC. Hypertrophic cardiomyopathy-linked mutation in troponin T causes myofibrillar disarray and pro-arrhythmic action potential changes in human iPSC cardiomyocytes. J Mol Cell Cardiol. 2018 Jan;114:320-327. doi: 10.1016/j.yjmcc.2017.12.002. Epub 2017 Dec 5. PubMed PMID: 29217433; PubMed Central PMCID: PMC5800960.
纯度:≥98%
CAS:147527-31-9