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白细胞介素1受体相关激酶1结合蛋白1抗体
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

产品名称
Anti-Irak1bp1
Anti-interleukin-1 receptor-associated kinase 1 binding protein 1 Antibody
产品介绍
靶标：

Irak1bp1


产品别名：

4921528N06Rik； AI851240； Aabp3； Aip70； Simpl； Irak1bp1； interleukin-1 receptor-associated kinase 1 binding protein 1； interleukin-1 receptor-associated kinase 1 binding protein 1； interleukin-1 receptor-associated kinase 1-binding protein 1； Acta binding protein 3； Acta-binding protein 70； IRAK1-binding protein 1； Plk-interacting protein； signaling molecule that associates with the mouse pelle-like kinase； 白细胞介素1受体相关激酶1结合蛋白1；


背景信息：
SIMPL, also known as IRAK1BP1 (interleukin-1 receptor-associated kinase 1-binding protein 1), is a 260 amino acid protein belonging to the IRAK1BP1 family. In addition to containing an intrinsically disordered region which associates with HSPA1 and HSPA8, SIMPL also interacts directly with IRAK1 and promotes RELA transcriptional activity. SIMPL is a major component of the IRAK1-dependent TNFRSF1A signaling pathway in which TNF-alpha induces NF-kappa-B gene transcription, leading to an inhibition of proinflammatory cytokines. Inactivation of SIMPL inhibits tumor necrosis factor receptor type I-induced NF-kappaB activity. Localizing to the nucleus and cytoplasm, SIMPL requires the phosphorylation of Ser-56 and/or Ser-62 to be fully active.

宿主：Rbt
类型：Pab
同种型:IgG  
应用：WB
纯化方式：亲和纯化
偶联物：Unconjugated
性状：液体
存储溶液：参阅说明书
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user           
储存：经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。