靶标：
ARHGAP21
产品别名：
ARHGAP10； ARHGAP21； Rho GTPase activating protein 21； Rho GTPase activating protein 21； rho GTPase-activating protein 21； Rho-GTPase activating protein 10； rho GTPase-activating protein 10； rho-type GTPase-activating protein 21；
背景信息：
ARHGAP family genes, such as FNBP2, SRGAP1/ARHGAP13, SRGAP2/ARHGAP14, ARHGAP4 and AHRGAP20/KIAA1391, encode GTPase activating proteins for Rho family proteins (RhoGAPs). ARHGAP21 controls the Arp2/3 complex and F-actin dynamics at the Golgi complex by regulating the activity of the small GTPase Cdc42. ARHGAP21 is recruited to the Golgi by binding to another small GTPase, ARF1. ARHGAP21 associates with many proteins and modulates several cellular functions, including actin cytoskeleton rearrangement in different tissues. ARHGAP21involves in cell-cell junction remodeling and that ARHGAP21 affects migration and epithelial-mesenchymal transition (EMT) through α-tubulin interaction and acetylation. ARHGAP21 has been implicated in adhesion and migration of cancer cells. ARHGAP21 is a RhoGAP with increased expression in head and neck squamous cell carcinoma and with a possible role in glioblastoma tumor progression.
宿主：Rbt
类型：Pab
同种型:IgG
应用：WB
纯化方式：亲和纯化
偶联物：Unconjugated
性状：液体
存储溶液：参阅说明书
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
稀释比例: Optimal dilutions/concentrations should be determined by the end user
储存：经常使用则4°C保存。-20°C保存不超过两年。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
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