TOX high mobility group box family member 4 (TOX4), also known as epidermal Langerhans cell protein 1 (LCP1), is a 621 amino acid protein that localizes to the nucleus. Mapping to chromosome 14q11.2, TOX4 contains one high mobility group (HMG) box DNA-binding domain, corresponding to amino acids 223 to 291 of human TOX4. The HMG box domain is a region of about 80 amino acids with unusual DNA binding preferences. HMG proteins bind DNA without sequence specificity. Furthermore, they bind to distorted or modified DNA and have the property to bend DNA. The presence of the HMG box DNA-binding domain suggests that TOX4 plays a role in transcriptional regulation.