SB 612111 HCl is a selective NOP receptor antagonist (Kis are 0.33, 57.6, 160.5 and 2109 nM for NOP, μ-, κ- and δ-receptors respectively). It antagonizes the pronociceptive action of nociceptin (Cat. No. 0910) in an acute pain model. SB 612111 HCl potentiates the action of morphine in morphine-tolerant animals and blocks hyperalgesia in an inflammatory pain model. References: Hardaway JA, Jensen J, Kim M, Mazzone CM, Sugam JA, Diberto JF, Lowery-Gionta EG, Hwa LS, Pleil KE, Bulik CM, Kash TL. Nociceptin receptor antagonist SB 612111 decreases high fat diet binge eating. Behav Brain Res. 2016 Jul 1;307:25-34. doi: 10.1016/j.bbr.2016.03.046. Epub 2016 Mar 29. PubMed PMID: 27036650; PubMed Central PMCID: PMC4896639.

纯度：≥98%

CAS：371980-94-8