NS3763 is a noncompetitive antagonist of GLUK5 receptor. NS3763 exhibits selectivity for inhibition of domoate-induced increase in intracellular calcium mediated through the GLU(K5) subtype (IC(50) = 1.6 microM) of kainate receptors compared with the GLU(K6) subtype (IC(50) > 30 microM). NS3763 inhibits the GLU(K5)-mediated response in a noncompetitive manner. NS3763 selectively inhibits l-glutamate- and domoate-evoked currents through GLU(K5) receptors in HEK293 cells. References: Lv Q, Liu Y, Han D, Xu J, Zong YY, Wang Y, Zhang GY. Neuroprotection of GluK1 kainate receptor agonist ATPA against ischemic neuronal injury through inhibiting GluK2 kainate receptor-JNK3 pathway via GABA(A) receptors. Brain Res. 2012 May 25;1456:1-13. doi: 10.1016/j.brainres.2012.03.050. Epub 2012 Mar 28. PubMed PMID: 22516108.

纯度：≥98%

CAS：70553-45-6