基因名：
BMI1
产品别名：
FLVI2/BMI1； PCGF4； RNF51； flvi-2/bmi-1； BMI1； BMI1 proto-oncogene, polycomb ring finger； BMI1 proto-oncogene, polycomb ring finger； polycomb complex protein BMI-1； B lymphoma Mo-MLV insertion region 1 homolog； BMI1 polycomb ring finger oncogene； BMI1 polycomb ring finger proto-oncogene； murine leukemia viral (bmi-1) oncogene homolog； polycomb group RING finger protein 4； polycomb group protein Bmi1； ring finger protein 51； 多梳家族环指蛋白4(PCGF4)； 组蛋白相关Bmi1；
背景信息：
The Bmi1 oncogene induces telomerase activity and immortalizes human mammary epithelial cells. Bmi1 extends the replicative life span of human fibroblasts by suppressing the p16-dependent senescence pathway.
Polycomb group (PcG) genes are involved in the maintenance of cellular memory through epigenetic chromatin modifications. Recent studies have implicated a role for PcG genes in the self-renewal of hematopoietic stem cells (HSCs), a process in which cellular memory is maintained through cell division. Among the PcG genes, Bmi1 plays a central role in the inheritance of stemness, and its forced expression promotes HSC self-renewal. These findings highlight the importance of epigenetic regulation in HSC self-renewal and identify PcG genes as potential targets for therapeutic HSC manipulation. Involved in maintaining the transcriptionally repressive state of genes. Modifies chromatin, rendering it heritably changed in its expressibility.
标签：His-tag
分类：Recombinant
类型：Protein
偶联物：Unconjugated
内毒素水平：按批次，参阅瓶身标签
性状:Liquid
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型：purified
内含物：不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存：2-8°C不超过一个月，-80°C不超过12个月。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。
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