SC99 is a selective inhibitor of JAK2-STAT3 activation. SC99 downregulates the expression of STAT3-modulated genes, including Bcl-2, Bcl-xL, VEGF, cyclin D2, and E2F-1. References: Ding Y, Qian J, Li H, Shen H, Li X, Kong Y, Xu Z, Chen G. Effects of SC99 on cerebral ischemia-perfusion injury in rats: Selective modulation of microglia polarization to M2 phenotype via inhibiting JAK2-STAT3 pathway. Neurosci Res. 2018 May 12. pii: S0168-0102(17)30594-1. doi: 10.1016/j.neures.2018.05.002. [Epub ahead of print] PubMed PMID: 29763638.

纯度：≥98%

CAS：882290-02-0