重组α-1抗胰蛋白酶

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重组α-1抗胰蛋白酶

本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。

产品名称

重组α1-抗胰蛋白酶(a1AT)
Recombinant SERPINA1

产品介绍

基因名：

SERPINA1

产品别名：

A1A； A1AT； AAT； PI； PI1； PRO2275； alpha1AT； nNIF； SERPINA1； serpin family A member 1； serpin family A member 1； alpha-1-antitrypsin； alpha-1 antitrypsin； alpha-1 protease inhibitor； alpha-1 proteinase inhibitor； alpha-1-antiproteinase； anti-elastase； epididymis secretory sperm binding protein； protease inhibitor 1 (anti-elastase), alpha-1-antitrypsin； serine (or cysteine) proteinase inhibitor, clade A, member 1； serpin A1； serpin peptidase inhibitor clade A (alpha-1antiproteinase, antitrypsin) member 1； serpin peptidase inhibitor clade A member 1； serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1； α-1抗胰蛋白酶； α1-抗胰蛋白酶(a1AT)；

背景信息：

Serpin A1 is a prototype member of the Serpin superfamily of the serine protease inhibitors. As one of the most abundant proteinase inhibitors in the circulation, it is synthesized in hepatocytes, and to a lesser extent, in macrophages as well as intestinal epithelial cell lines and secreted as the abundant proteinase inhibitor in the circulation whose targets include elastase, plasmin, thrombin, trypsin, chymotrypsin, and plasminogen activator. Point mutations in the native SerpinA1 variants result in Serpin A1 deficiency, and consequently lead to several clinical complications such as pulmonary emphysema, juvenile hepatitis, cirrhosis, and hepatocellular carcinoma. For example, the Z variants (Glu342 to Lys) forms intracellular inclusion bodies, is not secreted, and leads to a severe SerpinA1 deficiency. Accordingly, Serpin A1 deficiency in circulation is associated with emphysema or liver disease.

标签：His-tag
分类：Recombinant
类型：Protein
偶联物：Unconjugated
内毒素水平：按批次，参阅瓶身标签
性状:Liquid
浓度：Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型：purified
内含物：不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存：2-8°C不超过一个月，-80°C不超过12个月。避免反复冻融。
注意事项：仅供实验室使用。不适用于人类或动物的任何临床，治疗或诊断用途。不适合动物或人类食用。