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Clorsulon(MK-401 L631529)
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Clorsulon(MK-401 L631529)图片
CAS NO:60200-06-8
规格:≥98%
包装与价格:
包装价格(元)
100mg电议
250mg电议
500mg电议
1g电议
2g电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)380.66
FormulaC8H8Cl3N3O4S2
CAS No.60200-06-8
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 76 mg/mL (199.7 mM)
Water: <1 mg/mL
Ethanol: 7 mg/mL (18.4 mM)
Solubility (In vivo)1% DMSO+30% polyethylene glycol+1% Tween 80: 30 mg/mL
SynonymsMK 401; MK-401; MK401; L-631529; L631529; L 631529; L-631,529; L631,529; L 631,529; Clorsulone; Clorsulonum; BRN 2821757; BRN2821757; BRN-2821757
实验参考方法
In Vitro

In vitro activity: Clorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro. Clorsulon is used in the treatment of Fasciola hepatica infections in calves and sheep. Target: Antiparasitic Clorsulon is a competitive inhibitor of both 3-phosphoglycorate and ATP and had a Ki of 0.29 mM, inhibits glucose utilization and acetate and propionate formation by mature Fasciola hepatica in vitro.

In VivoClorsulon (a single dose of 15 mg/kg) is effective in removing over 90% of immature Fasciola hepatica from sheep (6 weeks after infection) and calves (8 weeks after infection). A 2.5 mg/kg dose removed over 90% of mature (16 weeks old) liver fluke from sheep. Clorsulon causes severe disruption to the tegument and gut of Fasciola hepatica after in vivo incubation.
Animal modelRat
Formulation & DosageFormulated in 1:2 mixture of polyethylene glycol 400:dimethyl sulphoxide; 12.5 mg/kg; p.o.
ReferencesJ Med Chem. 1977 Sep;20(9):1225-7; Mol Biochem Parasitol. 1982 Mar;5(3):133-45; Parasitol Res. 2004 Feb;92(3):232-41.