您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > 重组选择性胸腺细胞相关蛋白
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
重组选择性胸腺细胞相关蛋白
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。

产品名称
Recombinant Themis
Recombinant thymocyte selection associated protein
产品介绍
基因名:

Themis


产品别名:

E430004N04Rik; Gasp; Spot; Tsepa; thylex; Themis; thymocyte selection associated; thymocyte selection associated; protein THEMIS; grb2-associating protein; signaling phosphoprotein specific for T cells; thymocyte selection pathway associated; thymocyte-expressed molecule involved in selection; thymus lymphocyte exclusively expressed; 选择性胸腺细胞相关蛋白;


背景信息:
Themis is a 641 amino acid nuclear and cytoplasmic protein that exists as three alternatively spliced isoforms. Themis belongs to the themis family and interacts with PLC γ1, Emt and GRB2. Acting through T-cell antigen receptor (TCR) signaling and through the regulation of calcium influx and phosphorylation of ERK 1, Themis plays a central role in late thymocyte development by controlling both positive and negative T-cell selection. Themis is phosphorylated on Tyr residues quickly after TCR stimulation. The gene that encodes Themis maps to human chromosome 6q22.33. With 170 million base pairs, chromosome 6 comprises nearly 6% of the human genome. Deletion of a portion of the q arm of chromosome 6 is associated with early onset intestinal cancer, suggesting the presence of a cancer susceptibility locus. Additionally, Porphyria cutanea tarda, Parkinson's disease, Stickler syndrome and a susceptibility to bipolar disorder are all associated with genes that map to chromosome 6.

标签:His-tag   
分类:Recombinant  
类型:Protein   
偶联物:Unconjugated
内毒素水平:按批次,参阅瓶身标签
性状:Liquid
浓度:Batch dependent (Please refer to the vial label for the specific concentration.)
纯化类型:purified
内含物:不含防腐剂
应用:Positive Control;Immunogen;SDS-PAGE;WB.
储存:2-8°C不超过一个月,-80°C不超过12个月。避免反复冻融。
注意事项:仅供实验室使用。不适用于人类或动物的任何临床,治疗或诊断用途。不适合动物或人类食用。