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Isosorbide Dinitrate
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:87-33-2
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

Isosorbide dinitrate is an organic nitrate ester and nitric oxide (NO) donor in the same class as nitroglycerin. It induces vasodilation with IC50 of 0.56 and 1.82 μM for isolated precontracted rabbit femorally bioavailable vein and artery, respectively. Isosorbide dinitrate increases oxygenation of tumor tissue in vivo in a mouse xenograft model. It also inhibits platelet aggregation in vitro and in vivo at concentrations in the micromolar range. Formulations containing isosorbide dinitrate have been used for the treatment of angina pectoris. References: Cossu MV, Cattaneo D, Fucile S, Pellegrino P, Baldelli S, Cozzi V, Capetti A, Clementi E. Combined isosorbide dinitrate and ibuprofen as a novel therapy for muscular dystrophies: evidence from Phase I studies in healthy volunteers. Drug Des Devel Ther. 2014 May 2;8:411-9. doi: 10.2147/DDDT.S58803. eCollection 2014. PubMed PMID: 24851040; PubMed Central PMCID: PMC4018313.

纯度:≥98%

CAS:87-33-2