HJB-97 is a novel, potent and high affinity inhibitor of BET bromodomain with Ki values of 0.9 nM (BRD2 BD1), 0.27 nM (BRD2 BD2), 0.18 nM (BRD3 BD1), 0.21 nM (BRD3 BD2), 0.5 nM (BRD4 BD1), 1.0 nM (BRD4 BD2), respectively. It acts by targeting BRD2/3/4 BD1 and BD2. It is used for the design and synthesis of PROTAC-based BET degrader with antitumor activity.

纯度：≥98%

CAS：2093391-24-1