GW-813893, formerly known as GSK-813893, is a potent, selective and orally bioavailable factor Xa inhibitor potentially for the treatment of thromboembolism. GW813893 was more than 90-fold selective over all enzymes tested, and it inhibited FXa and prothrombinase activity with a Ki of 4.0 nM and 9.7 nM, respectively. In vivo, GW813893 concentration-dependently suppressed thrombotic activity in all models tested. References: Abboud MA, Needle SJ, Burns-Kurtis CL, Valocik RE, Koster PF, Amour AJ, Chan C, Brown D, Chaudry L, Zhou P, Patikis A, Patel C, Pateman AJ, Young RJ, Watson NS, Toomey JR. Antithrombotic potential of GW813893: a novel, orally active, active-site directed factor Xa inhibitor. J Cardiovasc Pharmacol. 2008 Jul;52(1):66-71. doi: 10.1097/FJC.0b013e31817e9b9e. PubMed PMID: 18645410.

纯度：≥98%

CAS：478644-12-1