GYKI-13324 is bifunctional nitrosoureido analogue and alkylating agent. GYKI-13324 was studied on human colorectal tumor xenograft lines. Given orally in single or multiple daily doses, GYKI-13324 produced long-term or total regression of adenomatous, but only marginal growth delay of mucinous tumors. GYKI-13324, with slightly lower toxicity than that of BCNU, seems to be a candidate in the clinical management of colorectal tumors. References: Pál K, Kopper L, Lapis K. Chemotherapeutic sensitivity of liver metastases from intrasplenically-growing Lewis lung tumor. Clin Exp Metastasis. 1983 Oct-Dec;1(4):341-7. PubMed PMID: 6443744.

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CAS：76123-41-6