GR 113808 is a potent, selective 5-HT4 receptor antagonist (pKB = 9.43 in human colonic muscle, and Kd = 0.15 nM for binding to cloned human 5-HT4 receptors). GR 113808 exhibits > 300-fold selectivity over 5-HT1A, 5-HT1B, 5-HT2A, 5-HT2C and 5-HT3 receptors. References: Castro L, Varjao B, Silva I, Duque B, Batista A, Santana R, Luz P, Rocha MA Jr, Fregoneze JB, De Castro-e-Silva E. Effect of the intracerebroventricular administration of GR 113808, a selective 5-HT4 antagonist, on water intake during hyperosmolarity and hypovolemia. Braz J Med Biol Res. 2001 Jun;34(6):791-6. PubMed PMID: 11378670.

纯度：≥98%

CAS：144625-51-4