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UPGL00004
本产品不向个人销售，仅用作科学研究，不用于任何人体实验及非科研性质的动物实验。
UPGL00004图片
CAS NO:1890169-95-5
规格:≥98%
包装与价格：
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW) 534.66
Formula C25H26N8O2S2
CAS No. 1890169-95-5
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 25 mg/mL
Water: N/A
Ethanol: N/A
Chemical Name 2-Phenyl-N-(5-(4-((5-(2-phenylacetamido)-1,3,4-thiadiazol-2-yl)amino)piperidin-1-yl)-1,3,4-thiadiazol-2-yl)acetamide
Synonyms UPGL00004; UPGL-00004; UPGL 00004
SMILES Code O=C(NC1=NN=C(N2CCC(NC3=NN=C(NC(CC4=CC=CC=C4)=O)S3)CC2)S1)CC5=CC=CC=C5
实验参考方法
Target

IC50: 29 nM (Glutaminase C)[1] Kd: 27 nM (Glutaminase C)[1]
In Vitro UPGL00004 inhibits MDA-MB-231, HS578T and TSE cells with IC50s of 70, 129, and 262 nM, respectively[1].
In Vivo The combination of UPGL00004 (1 mg/kg body weight) and Bevacizumab (2.5 mg/kg body weight) via intraperitoneal injection completely prevent any detectable increase in tumor size in a triple-negative breast cancer patient-derived tumor graft model[1].
References

[1]. Characterization of the interactions of potent allosteric inhibitors with glutaminase C, a key enzyme in cancer cell glutamine metabolism. J Biol Chem. 2018 Mar 9;293(10):3535-3545