Tecarfarin (ATI5923) is a potent, non-competitive and orally bioavailable vitamin K epoxide reductase (VKOR) inhibitor with antithrombotic activity by impairing the activation of the vitamin K-dependent clotting factors II, VII, IX and X. Like warfarin, tecarfarin attenuates venous and arterial thrombus formation in animal models by reducing the levels of the vitamin K-dependent coagulation factors. ecarfarin, via a vitamin K-dependent mechanism, causes changes in key parameters of haemostasis in beagle dogs that are consistent with effective anticoagulation. Compared to warfarin it has a decreased potential to interact metabolically with drugs that inhibit CYP450 enzymes and, therefore, may offer an improved safety profile for patients.

纯度：≥98%

CAS：867257-26-9