FR-186054 is a new, potent, orally efficacious inhibitor of acyl-cholesterol O-acyltransferase (ACAT). This compound displayed excellent in vitro efficacy, irrespective of dosing method, indicating superior characteristics compared to other ACAT inhibitors. References: Tanaka A, Terasawa T, Hagihara H, Kinoshita T, Sakuma Y, Ishibe N, Sawada M, Takasugi H, Tanaka H. Synthesis, X-ray crystal structure, and biological activity of FR186054, a novel, potent, orally active inhibitor of acyl-CoA:cholesterol O-acyltransferase (ACAT) bearing a pyrazole ring. Bioorg Med Chem Lett. 1998 Jan 6;8(1):81-6. PubMed PMID: 9871633.

纯度：≥98%

CAS：179053-90-8