FR-188582 is a highly selective inhibitor of COX-2. It has anti-inflammatory and ulcerogenic effects. FR188582 inhibited COX-2 with an IC50 of 0.017 microM, and the inhibition of prostaglandin (PG) E2 formation by FR188582 was over 6000 times more selective for COX-2 than COX-1. FR-188582 has potent anti-inflammatory effect mediated by inhibition of PGE2 in inflamed tissues. References: Abe T, Hayasaka Y, Zhang XY, Hayasaka S. Effects of intravenous administration of FR122047 (a selective cyclooxygenase 1 inhibitor) and FR188582 (a selective cyclooxygenase 2 inhibitor) on prostaglandin-E2-induced aqueous flare elevation in pigmented rabbits. Ophthalmic Res. 2004 Nov-Dec;36(6):321-6. PubMed PMID: 15627832.

纯度：≥98%

CAS：189699-82-9