Foxy-5 is a wnt signalling pathway modulator potentially forthe treatment of metastatic breast cancer, prostate cancer and colorectal cancer. In vitro analyses revealed that both recombinant Wnt-5a and the Wnt-5a-derived Foxy-5 peptide impaired migration and invasion without affecting apoptosis or proliferation of 4T1 breast cancer cells. The in vivo experiments show that i.p. injections of Foxy-5 inhibited metastasis of inoculated 4T1 breast cancer cells from the mammary fat pad to the lungs and liver by 70% to 90%. References: Ford CE, Ekstrom EJ, Howlin J, Andersson T. The WNT-5a derived peptide, Foxy-5, possesses dual properties that impair progression of ERalpha negative breast cancer. Cell Cycle. 2009 Jun 15;8(12):1838-42. Review. Retraction in: Andersson T, Ford CE, Ekstrom EJ, Howlin J. Cell Cycle. 2011 Apr 1;10(7):1167. PubMed PMID: 19448401.

纯度：≥98%

CAS：881188-51-8