FR 113680 is a novel tripeptide substance P antagonist with NK1 receptor selectivity. The inhibitory effect of FR 113680 on SP-induced guinea-pig ileum contraction is competitive and the pA2 value is 7.53. It suggest that FR 113680 interacts selectively with the NK1 neurokinin receptor. References: Caliendo G, Greco G, Grieco P, Perissutti E, Santagada V, Calignano A, Mancuso F, Novellino E. Synthesis and in vitro activities of highly potent and selective tripeptide antagonists of the neurokinin NK-1 receptor. Farmaco. 1995 Nov;50(11):755-9. PubMed PMID: 8593172.

纯度：≥98%

CAS：126088-92-4