CBT is a MDR modulator, is also a naturally-occurring, orally bioavailable bisbenzylisoquinoline plant alkaloid with potential chemosensitization activity. MDR modulator CBT-1 binds to and inhibits the MDR efflux pump P-glycoprotein (P-gp), which may inhibit the efflux of various chemotherapeutic agents from tumor cells and reverse P-gp-mediated tumor cell MDR. P-gp is a transmembrane ATP-binding cassette (ABC) transporter and is overexpressed by some multidrug resistant tumors. References: Meher AH, Shrivastav SS, Vibhute PJ, Hazarey PV. Deflection and stress distribution around mini-screw implants: a finite element investigation into the effect of cortical bone thickness, force magnitude and direction. J Orthod. 2012 Dec;39(4):249-55. doi: 10.1179/1465312512Z.00000000037. PubMed PMID: 23269688.

纯度：≥98%