Fosfomycin Tromethamine (MK0955) is a potent, blood-brain barrier penetrant phosphoenolpyruvate
analog produced by Streptomyces and a synthetic broad-spectrum
antibiotic with antimicrobial and bactericidal properties. Fosfomycin
binds to and inactivates the enzyme enolpyruvate transferase. This leads
to an irreversible blockage of the condensation of uridine
diphosphate-N-acetylglucosamine with p-enolpyruvate, which is one of the
first steps of bacterial cell wall synthesis.