Foropafant, formerly known as SR-27417; SR-27417A, is a potent platelet activating factor (PAF) inhibitor potentially for the treatment of asthma and allergic rhinitis (AR). SR 27417 inhibits in a dose-dependent manner the hypotensive effect of PAF in rats. It protected rats with an ED50 value of 6 +/- 2 micrograms/kg (n = 6), when given i.v., 1 min before PAF administration. PAF plays a major role in anaphylactic shock. SR 27417 may be an effective prophylactic as well as a potent curative drug in this pathology. References: Bélanger C, Elimam H, Lefebvre J, Borgeat P, Marleau S. Involvement of endogenous leukotriene B4 and platelet-activating factor in polymorphonuclear leucocyte recruitment to dermal inflammatory sites in rats. Immunology. 2008 Jul;124(3):295-303. doi: 10.1111/j.1365-2567.2007.02767.x. Epub 2008 Jan 24. PubMed PMID: 18217950; PubMed Central PMCID: PMC2440823.

纯度：≥98%

CAS：136468-36-5