Org-31710 is a progesterone receptor antagonist potentially for contraception. ORG-31710 induced transient up-regulation of inhibitor of apoptosis XIAP. The presence of swollen microvilli, precursors of endometrial pinopodes, was significantly reduced on cultures with Org 31710. The presence of Org 31710 significantly decreased the levels of PGE(2), PGF(2 alpha), and PA activity. These results suggest that P is essential in ovulation during the initial stages of the ovulatory process. References: Goyeneche AA, Seidel EE, Telleria CM. Growth inhibition induced by antiprogestins RU-38486, ORG-31710, and CDB-2914 in ovarian cancer cells involves inhibition of cyclin dependent kinase 2. Invest New Drugs. 2012 Jun;30(3):967-80. doi: 10.1007/s10637-011-9655-z. PubMed PMID: 21424700; PubMed Central PMCID: PMC3348464.

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CAS：118968-41-5