TG693 is a novel, potent, orally bioavailable, selective, ATP-competitive Cdc2-like Kinases (CLK1) inhibitor with IC50 of 112.6 nM. It also potently inhibits haspin activity and weakly inhibits DYRK kinases in a panel of 313 recombinant kinases; promotes the skipping of the endogenous mutated exon 31 in DMD patient-derived cells and increases the production of the functional exon 31-skipped dystrophin protein; inhibits the phosphorylation of CLK1 substrate serine/arginine-rich proteins and modulates pre-mRNA splicing in the skeletal muscle in mice.

纯度：≥98%

CAS：885272-55-9