| CAS NO: | 81702-42-3 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| 500mg | 电议 |
| Molecular Weight (MW) | 291.77 |
|---|---|
| Formula | C16H17NO2 . HCl |
| CAS No. | 81702-42-3 (R-isomer HCl); |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Solubility (In vitro) | DMSO: 58 mg/mL (198.8 mM) |
| Water: <1 mg/mL | |
| Ethanol: 6 mg/mL (20.6 mM) | |
| SMILES Code | OC1=C(O)C=C2C(C3=CC=CC=C3)CNCCC2=C1.[H]Cl |
| Synonyms | SKF-38393; SKF 38393; SKF38393; SKF-38,393; SKF 38,393; SKF38,393; SKF-38393 HCl; SKF-38393 hydrochloride; SKF-38393A; SKF 38393A; SKF38393A; R(+)-SKF-38393A; R(+) SKF 38393A; R(+)SKF38393A; R-SKF-38393A; R SKF 38393A; RSKF38393A; |
| In Vitro | In vitro activity: SKF38393 (50-100 μM) induces long-lasting synaptic potentiation in a protein synthesis-dependent manner. In rat prefrontal cortical neurons in vitro, SKF 38393 mimicks the effects of DA on I(NaP), and modulates a persistent sodium current. In the auditory cortex, SKF38393 affects long-term memory formation and consolidation by activating the downstream effectors adenylyl cyclase and phospholipase C-prominent proteomic alterations. Kinase Assay: SKF 38393 hydrochloride is a D1 agonist with IC50 of 110 nM. Cell Assay: |
|---|---|
| In Vivo | SKF 38393(6 mg/kg, i.p.) prevents the scopolamine-induced impairment of performance of a T-maze working memory task. In adult male NMRI mice, SKF38393 (1 μg/mouse) impaires context-dependent fear learning. |
| Animal model | Male Wistar rats |
| Formulation & Dosage | Dissolved in saline; 6 mg/kg; i.p. injection |
| References | Proc Natl Acad Sci U S A. 1995 Mar 28;92(7):2446-50; Eur J Pharmacol. 2007 Dec 22;577(1-3):71-7. |
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