Toremifene (NSC 613680; NK 622; FC 1157a) is an orally bioavailable and second-generation SERM (selective estrogen receptor modulator) used in the treatment of advanced breast cancer. Toremifene citrate acts by antagonizing the actions of estrogen in the body. Toremifene (7.5 mM) causes approximately 60% of the cells to exhibit morphologic characteristics typical of cells undergoing programmed death, or apoptosis in human breast cancer cells. Toremifene (5-10 mM) results in elevated levels of TRPM-2 and TGF beta 1 mRNAs in in vitro or in vivo grown tumor cells.

纯度：≥98%

CAS：89778-26-7