Lexithromycin (Erythromycin A 9-methoxime; Wy 48314) is a potent and semi-synthetic antibiotic derived from erythromycin A with antibacterial activity. It is prepared by reaction of the 9-keto moiety to methyl oxime. The structural change improves the pH stability profile and hydrophobicity of lexithromycin for better in vivo absorption. Thus lexithromycin has improved absorption in vivo over erythromycin due to increased hydrophopicity and pH stability. As with other macrolides, lexithromycin prevents protein synthesis by binding the ribosome at the polypeptide exit tunnel. Formulations containing lexithromycin were tested in clinical trials as treatment for HIV but were discontinued.

纯度：≥98%

CAS：53066-26-5