| CAS NO: | 1809427-19-7 |
| 规格: | ≥98% |
| 包装 | 价格(元) |
| 10mg | 电议 |
| 25mg | 电议 |
| 50mg | 电议 |
| 100mg | 电议 |
| 250mg | 电议 |
| Name: DT-061 CAS#: 1809427-19-7 Chemical Formula: C25H23F3N2O5S Exact Mass: 520.128 Molecular Weight: 520.5232 | |
| Storage | -20℃ for 3 years in powder form |
| -80℃ for 2 years in solvent | |
| Technical Information | Synonym: DT 061; DT61; SMAP; DT-061; DT061; DT-61; DT 61 Chemical Name: N-((1R,2R,3S)-2-hydroxy-3-(10H-phenoxazin-10-yl)cyclohexyl)-4-(trifluoromethoxy)benzenesulfonamide InChi Key: WGKGADVPRVLHHZ-ZHRMCQFGSA-N InChi Code: InChI=1S/C25H23F3N2O5S/c26-25(27,28)35-16-12-14-17(15-13-16)36(32,33)29-18-6-5-9-21(24(18)31)30-19-7-1-3-10-22(19)34-23-11-4-2-8-20(23)30/h1-4,7-8,10-15,18,21,24,29,31H,5-6,9H2/t18-,21+,24+/m1/s1 SMILES Code: O=S(C1=CC=C(OC(F)(F)F)C=C1)(N[C@H]2[C@H](O)[C@@H](N3C4=C(C=CC=C4)OC5=CC=CC=C35)CCC2)=O |
| Target | PP2A[1]. |
|---|---|
| In Vivo | DT-061 (5 mg/kg, oral gavage, 4 weeks) shows single-agent activity in inhibiting H358 or H441 xenograft growth. Additionally, the combination of DT-061 and AZD6244 is more significantly efficient[1]. Animal Model: 6- to 8-week-old male BALB/c nu/nu mice injected with H441 cells (5 × 106)[1]. Dosage: 5 mg/kg. Administration: Oral gavage for 4 weeks. Result: Showed activity in inhibiting tumor growth. |
| References | [1]. Sci Transl Med. 2018 Jul 18;10(450). pii: eaaq1093. |
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