BRD4354 is an inhibitor of HDAC5 and HDAC9. BRD4354 has IC50 of 0.85 μM and 1.88 μM for HDAC5 and HDAC9 respectively. Inhibition of other HDACs was lower, with IC50 of 3.88-13.8 μM for HDACs 4, 6, 7, and 8 and over 40 μM for HDACs 1, 2, and 3. References: Boskovic ZV, Kemp MM, Freedy AM, Viswanathan VS, Pop MS, Fuller JH, Martinez NM, Figueroa Lazú SO, Hong JA, Lewis TA, Calarese D, Love JD, Vetere A, Almo SC, Schreiber SL, Koehler AN. Inhibition of Zinc-Dependent Histone Deacetylases with a Chemically Triggered Electrophile. ACS Chem Biol. 2016 Jul 15;11(7):1844-51. doi: 10.1021/acschembio.6b00012. PubMed PMID: 27064299.

纯度：≥98%

CAS：315698-07-8