DK-1-49 is an autophagonizer. DK-1-49 causes accumulation of autophagy-associated LC3-II and enhanced levels of autophagosomes and acidic vacuoles. Furthermore, cell viability is inhibited by autophagic cell death in not only human cancer cells but also Bax/Bak double-knockout cells. References: Nguyen J, Chen L, Kumar D, Lee J. Facile synthesis of autophagonizer and evaluation of its activity to induce autophagic cell death in apoptosis-defective cell line. Bioorg Med Chem Lett. 2016 Oct 1;26(19):4753-6. doi: 10.1016/j.bmcl.2016.08.035. Epub 2016 Aug 13. PubMed PMID: 27597252.

纯度：≥98%

CAS：853136-76-2