BRD6989 is an analog of the naturally occurng cortistatin A (dCA), acting as a novel, potent and selective CDK8 inhibitor with an IC50 of ~200 nM. The ability of BRD6989 to upregulate IL-10 is recapitulated by multiple, structurally differentiated CDK8 and CDK19 inhibitors and requires an intact cyclin C-CDK8 complex. BRD6989 demonstrated a high selectivity for CDK8 over CDK19. In bone-marrow-derived dendritic cells, BRD6989 suppressed the phosphorylation of STAT1 at S727 and enhanced the production of IL-10, suggesting CDK8 as a negative regulator of IL-10 production during innate immune activation. BRD6989 may be useful for inflammatory disorders.

纯度：≥98%

CAS：642008-81-9