CAS NO: | 2170867-89-5 |
规格: | ≥98% |
包装 | 价格(元) |
10mg | 电议 |
25mg | 电议 |
50mg | 电议 |
100mg | 电议 |
Diprovocim is a novel and potent agonist of Toll-like receptor (TLR1/TLR2) with anticancer and immunomodulatory effects. It induces dose-dependent TNF production with an EC50 of 110 pM in human THP-1 cells and 1.3 nM in primary mouse peritoneal macrophages. Inducing TNF production in bone marrow-derived dendritic cells (BMDC) with EC50 of 6.7 nM, also inducing IL-6 production by mouse BMDC; inducing phosphorylation of IKKα, IKKβ, p38, JNK, and ERK, as well as degradation of IκBα in THP-1 cells and mouse peritoneal macrophages, activating conventional TLR1/TLR2 signaling, including MAPK and canonical NF-κB signaling; synergizes with anti-PD-L1 to eliminate melanoma in mice.
纯度:≥98%
CAS:2170867-89-5