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Diprovocim
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Diprovocim图片
CAS NO:2170867-89-5
规格:≥98%
包装与价格:
包装价格(元)
10mg电议
25mg电议
50mg电议
100mg电议

产品介绍

Diprovocim is a novel and potent agonist of Toll-like receptor (TLR1/TLR2) with anticancer and immunomodulatory effects. It induces dose-dependent TNF production with an EC50 of 110 pM in human THP-1 cells and 1.3 nM in primary mouse peritoneal macrophages. Inducing TNF production in bone marrow-derived dendritic cells (BMDC) with EC50 of 6.7 nM, also inducing IL-6 production by mouse BMDC; inducing phosphorylation of IKKα, IKKβ, p38, JNK, and ERK, as well as degradation of IκBα in THP-1 cells and mouse peritoneal macrophages, activating conventional TLR1/TLR2 signaling, including MAPK and canonical NF-κB signaling; synergizes with anti-PD-L1 to eliminate melanoma in mice.

纯度:≥98%

CAS:2170867-89-5