Description: BRL 54443 HCl is a potent agonist of 5-HT1E and 5-HT1F receptor with pKi of 8.7 and 9.25, respectively, with a weak binding affinity for 5-HT1A, 5-HT1B, 5-HT1D receptors. In studies using rat brain cortical membranes, BRL-54443 causes biphasic inhibition of total [3H]-5-HT. In C57BL/6J mouse aortae, BRL 54443 leads to a contraction in the presence of Ketanserin (an antagonist of 5-HT2A and 5-HT2C receptors).

References: Eur J Pharmacol. 2004 May 25;492(2-3):259-67; J Pharmacol Exp Ther. 2001 Apr;297(1):88-95.

纯度：≥98%

CAS：57477-39-1 (free base)