SP-23 (SP23) HCl is a first-in-class and potent STING-targeting PROTAC degrader with C-170 (STING inhibitor) as the warhead. It has anti-inflammatory effects. In degrades STING with a DC50 of 3.2 μM. SP23 exerted high anti-inflammatory efficacy in a cisplatin-induced acute kidney injury mouse model by modulating the STING signaling pathway. Taken together, SP23 represents the first PROTAC degrader of STING deserving further investigation as a new anti-inflammatory agent.