Butylidenephthalide is an inhibitor of platelet-derived growth factor (PDGF). Butylidenephthalide activity leads to the reduction of liver fibrosis, increased Nur77 (NR4A1) expression, and downregulation of EMT-related genes such as Snail (Snail/SNAI1) and Slug (Slug/SNAI2) References: Donkor PO, Chen Y, Ding L, Qiu F. Locally and traditionally used Ligusticum species - A review of their phytochemistry, pharmacology and pharmacokinetics. J Ethnopharmacol. 2016 Dec 24;194:530-548. doi: 10.1016/j.jep.2016.10.012. Epub 2016 Oct 10. Review. PubMed PMID: 27729283.

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CAS：551-08-6