NC1153 is a blocker of IL-2-induced activation of JAK3 and its downstream substrates STAT5a/b. It acts by promoting long-term allograft survival and sparing the recipient from multiple toxicities. References: Martinez GS, Ross JA, Kirken RA. Transforming Mutations of Jak3 (A573V and M511I) Show Differential Sensitivity to Selective Jak3 Inhibitors. Clin Cancer Drugs. 2016;3(2):131-137. doi: 10.2174/2212697X03666160610085943. PubMed PMID: 29046866; PubMed Central PMCID: PMC5642970.

纯度：≥98%

CAS：150661-91-9