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Carbazeran
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:70724-25-3
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

Carbazeran is an Aldehyde oxidase (AO) substrate and potent phosphodiesterase PDE-II and PDE-III inhibitor that produces concentration-dependent positive inotropic responses. Carbazeran shows chronotropic and inotropic effect in vivo (EC50 = 100 μM, ionotropic effects, independent of adrenergic mechanisms). It potently inhibits cAMP hydrolysis. In humans, the compound is almost completely cleared via 4-hydroxylation to the phthalazinone metabolite by AO. References: Manevski N, Balavenkatraman KK, Bertschi B, Swart P, Walles M, Camenisch G, Schiller H, Kretz O, Ling B, Wettstein R, Schaefer DJ, Pognan F, Wolf A, Litherland K. Aldehyde oxidase activity in fresh human skin. Drug Metab Dispos. 2014 Dec;42(12):2049-57. doi: 10.1124/dmd.114.060368. Epub 2014 Sep 23. PubMed PMID: 25249692.

纯度:≥98%

CAS:70724-25-3