Debio-0617B is a first-in-class multi-kinase inhibitor. Debio-0617B targets pSTAT3, pSTAT5, JAK, SRC, ABL, and class III/V RTKs. References: Murone M, Radpour R, Attinger A, Chessex AV, Huguenin AL, Schürch CM, Banz Y, Sengupta S, Aguet M, Rigotti S, Bachhav Y, Massière F, Ramachandra M, McAllister A, Riether C. The Multi-kinase Inhibitor Debio 0617B Reduces Maintenance and Self-renewal of Primary Human AML CD34(+) Stem/Progenitor Cells. Mol Cancer Ther. 2017 Aug;16(8):1497-1510. doi: 10.1158/1535-7163.MCT-16-0889. Epub 2017 May 3. PubMed PMID: 28468777.
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CAS:1332329-27-7