MS-245 is discontinued (DEA controlled substance). It is a tryptamine analogue which is used in scientific research. It acts as a selective 5-HT6 receptor antagonist with a Ki of 2.3 nM, and was derived through structure-activity relationship development of the selective 5-HT6 agonist EMDT. It has been used as a lead compound for further development of tryptamine-derived 5-HT6 antagonists. In animal studies it has been shown to boost the activity of, but not substitute for, both amphetamine and nicotine. References: Simon AA, Rowe JF, Gaulme P, Hammel HB, Casewell SL, Fortney JJ, Gizis JE, Lissauer JJ, Morales-Juberias R, Orton GS, Wong MH, Marley MS. NEPTUNE'S DYNAMIC ATMOSPHERE FROM KEPLER K2 OBSERVATIONS: IMPLICATIONS FOR BROWN DWARF LIGHT CURVE ANALYSES. Astrophys J. 2016 Feb 1;817(2). pii: 162. doi: 10.3847/0004-637X/817/2/162. PubMed PMID: 28127087; PubMed Central PMCID: PMC5257274.

纯度：≥98%

CAS：263384-65-2