CD-349 is a calcium channel antagonist potentially for the treatment of angina pectoris and hypertension. CD-349 inhibited the noradrenaline (NA)-induced contraction of aortas in Ca2(+)-free medium. The blocking effect of CD349 on neuronal Ca2+ influx, in combination with a cerebral vasodilatory action, may contribute to a favorable effect on ischemic brain damage. References: Miyata N, Yamaura H, Tsuchida K, Otomo S, Miyajima E. Role of cyclic GMP in inhibitory effects of CD-349 in isolated blood vessels. Gen Pharmacol. 1994 Mar;25(2):267-73. PubMed PMID: 8026725.
纯度:≥98%
CAS:88594-08-5