您好,欢迎来到试剂信息网! [登录] [免费注册]
试剂信息网
位置:首页 > 产品库 > DA-6886
立即咨询
咨询类型:
     
*姓名:
*电话:
*单位:
Email:
*留言内容:
请详细说明您的需求。
*验证码:
 
DA-6886
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
CAS NO:1645260-76-9
包装:50mg, 100mg, 250mg
规格:≥98%

产品介绍

DA-6886 is a 5-Hydroxytryptamine receptor 4 (5-HT4) agonist potentially for the treatment of irritable bowel syndrome. DA-6886 induced relaxation of the rat oesophagus preparation in a 5-HT4 receptor antagonist-sensitive manner. The evaluation of DA-6886 in CHO cells expressing hERG channels revealed that it inhibited hERG channel current with an pIC50 of 4.3, indicating that the compound was 1000-fold more selective for the 5-HT4 receptor over hERG channels. References: Lee MJ, Cho KH, Park HM, Sung HJ, Choi S, Im W. Pharmacological profile of DA-6886, a novel 5-HT4 receptor agonist to accelerate colonic motor activity in mice. Eur J Pharmacol. 2014 Jul 15;735:115-22. doi: 10.1016/j.ejphar.2014.03.061. PubMed PMID: 24769304.

纯度:≥98%

CAS:1645260-76-9