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Lappaconite HBr
本产品不向个人销售,仅用作科学研究,不用于任何人体实验及非科研性质的动物实验。
Lappaconite HBr图片
CAS NO:97792-45-5
规格:≥98%
包装与价格:
包装价格(元)
5mg电议
10mg电议
25mg电议
50mg电议
100mg电议
250mg电议
500mg电议

产品介绍
理化性质和储存条件
Molecular Weight (MW)665.61
FormulaC32H44N2O8.HBr
CAS No.97792-45-5
Storage-20℃ for 3 years in powder form
-80℃ for 2 years in solvent
Solubility (In vitro)DMSO: 28 mg/mL (42.1 mM)
Water: <1 mg/mL
Ethanol: <1 mg/mL
SMILESCCN1C[C@@]2(CC[C@@H]([C@@]34[C@@H]2C[C@@H](C31)[C@]5(C[C@@H]([C@H]6C[C@@H]4[C@@]5([C@H]6OC)O)OC)O)OC)OC(=O)C7=CC=CC=C7NC(=O)C.Br
SynonymsAllapinine
实验参考方法
In Vitro

In vitro activity: Lappaconite Hydrobromide is a kind of alkaloid extracted from Aconitum sinomontanum Nakai and has anti-inflammatory effects. Its absorption percentage in rat stomachs after administration was 9.67%.The absorption percentages at duodenum,jejunum,ileum and colon were 19.61%,11.83%,12.95% and 9.51%, respectively.When the concentration was raised from 10 mg/L to 40 mg/L, the uptake of lappaconite hydrobromide was linearly increased,whereas the absorption rate constant kept at the same level.

In VivoLappaconite Hydrobromide absorption percentage in rat stomachs after administration was 9.67%. The absorption percentages at colon, jejunum, ileum and duodenum were, 9.51%, 11.83%, 12.95%, and 19.61%, respectively. The uptake of lappaconite hydrobromide was linearly increased when the concentration was raised from 10 mg/L to 40 mg/L, whereas the absorption rate constant kept at the same level. The LD50 values are of 10.5 mg/kg (i.p. administration) and 9.9 mg/kg (i.p. administration) in mice and rat, respectively. In addition, in anesthetized rabbits injected with lappaconite up to 1 mg/kg, cardiac arrhythmia was quickly observed.
Animal modelMice and rats
Formulation & DosageLD50: Mice 10.5mg/kg (i.p.); Rats 9.9mg/kg (i.p.)
References

Biomed Chromatogr. 1990;4(1):43-6; J Nanobiotechnology. 2015;13:47; Nat Prod. 1979;42(6):615-23.